Effect of calcium pantothenate on physical fatigue and cognitive dysfunction in mice

• Published in: Nihon Eiyō, Shokuryō Gakkai shi Vol. 63; no. 1; pp. 9 - 16
• Main Authors: Nakagawasai, O., Tohoku Pharmaceutical Univ., Sendai (Japan), Onogi, H, Sato, A, Watanabe, H, Hiraga, H, Niijima, F, Tanno, K, Onda, M, Azumano, I, Furuta, S, Tadano, T
• Format: Journal Article
• Language: English; Japanese
• Published: Japan Society of Nutrition and Food Science 01.01.2010
• Subjects: ACIDE PANTOTHENIQUE; ACIDO PANTOTENICO; ALCALOIDE; ALCALOIDES; ALKALOIDS; calcium pantothenate; cognition; COMPLEMENT ALIMENTAIRE; COMPLEXE VITAMINIQUE B; fatigue; FUNCTIONAL DISORDERS; http://www.fao.org/aos/agrovoc#c_269; http://www.fao.org/aos/agrovoc#c_3144; http://www.fao.org/aos/agrovoc#c_33996; http://www.fao.org/aos/agrovoc#c_4795; http://www.fao.org/aos/agrovoc#c_5542; http://www.fao.org/aos/agrovoc#c_6633; http://www.fao.org/aos/agrovoc#c_8275; MICE; mouse; PANTOTHENIC ACID; RATON; RODENTIA; SOURIS; SUPLEMENTOS; SUPPLEMENTS; TRASTORNOS FUNCIONALES; TROUBLE FONCTIONNEL; VITAMINAS B; VITAMINS B
• ISSN: 0287-3516; 1883-2849
• DOI: 10.4327/jsnfs.63.9

The present study investigated whether calcium pantothenate has an anti-fatigue effect and/or is able to ameliorate cognitive deficit in mice. At 1.5 or 3 h after forced walking, mice were assessed for behavioral specificity, locomotor activity and swimming behavior in a forced swimming test, with or without administration of calcium pantothenate. We also examined the effect of calcium pantothenate on scopolamine-induced cognitive deficit using a Y-maze and passive avoidance task. Calcium pantothenate (administered orally at 300 or 600 mg/kg) significantly ameliorated the reduction of locomotor activity and swimming behavior after forced walking for 3 h. Mice that were not administered calcium pantothenate showed a significant reduction of locomotor activity relative to the treated group. However, acute or chronic administration of calcium pantothenate did not ameliorate the cognitive deficit induced by scopolamine in the Y-maze and passive avoidance tests. These results may have important implications in relation to prevention of physical fatigue using calcium pantothenate as a supplement.