Reversal of dialysis-dependent renal failure in light-chain deposition disease by autologous peripheral blood stem cell transplantation

Specific treatment of light-chain deposition disease has been reported as ineffective in altering the course of the severe or end-stage renal failure it causes. The authors describe a case of biopsy-proven primary light-chain deposition disease of the kidney, severe renal failure, and incipient dial...

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Bibliographic Details
Published inAmerican journal of kidney diseases Vol. 44; no. 3; p. 551
Main Authors Firkin, Frank, Hill, Prudence A, Dwyer, Karen, Gock, Hilton
Format Journal Article
LanguageEnglish
Published United States 01.09.2004
Subjects
Antineoplastic Agents, Alkylating - therapeutic use
Humans
Immunoglobulin Light Chains
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - therapy
Male
Melphalan - therapeutic use
Middle Aged
Paraproteinemias - complications
Peripheral Blood Stem Cell Transplantation
Remission Induction
Renal Dialysis
Transplantation, Autologous
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Summary:Specific treatment of light-chain deposition disease has been reported as ineffective in altering the course of the severe or end-stage renal failure it causes. The authors describe a case of biopsy-proven primary light-chain deposition disease of the kidney, severe renal failure, and incipient dialysis dependency, treated by autologous peripheral blood stem cell transplantation, that led to reversal of dialysis dependency and sustained improvement in renal function.
ISSN:1523-6838
DOI:10.1016/S0272-6386(04)00822-4