Heavy-atom-free triplet benzothiophene-fused BODIPY derivatives for lipid droplet-specific biomaging and photodynamic therapy

The twist fusion of a benzothiophene group and the introduction of a 4-methyloxystyryl donor group to the BODIPY core resulted in large spin–orbit coupling values and smaller singlet–triplet energy gaps for the novel infrared absorbed photosensitizers named BSBDP. They show a high reactive oxygen sp...

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Published inChemical communications (Cambridge, England) Vol. 60; no. 72; pp. 9809 - 9812
Main Authors Bu, Weibin, Yu, Changjiang, Man, Yingxiu, Li, Jiazhu, Wu, Qinghua, Gui, Shuangying, Wei, Yaxiong, Jiao, Lijuan, Hao, Erhong
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 05.09.2024
Subjects
Benzothiophene
Energy gap
Lipids
Photodynamic therapy
Spin-orbit interactions
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Summary:The twist fusion of a benzothiophene group and the introduction of a 4-methyloxystyryl donor group to the BODIPY core resulted in large spin–orbit coupling values and smaller singlet–triplet energy gaps for the novel infrared absorbed photosensitizers named BSBDP. They show a high reactive oxygen species efficiency exceeding 69% and a fluorescence quantum yield of 23% and are successfully applied in imaging-guided photodynamic therapy in vitro and in vivo .
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc02551b