N -Alkylation of amines with primary/secondary alcohols using a novel cobalt( ii ) inverse triazolyl-pyridine complex

Herein, we report a highly effective homogeneous methodology for the N -alkylation of amines with primary and secondary alcohols using a Co( ii )-complex of an inverse triazolyl-pyridine ligand. The developed methodology tolerates various functional groups to produce the desired N -alkylated product...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 60; no. 65; pp. 8581 - 8584
Main Authors Shekhawat, Bhawana, Gahlaut, Puneet Singh, Gautam, Deepak, Jana, Barun
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 09.08.2024
Subjects
Alcohols
Alkylation
Amines
Cobalt
Functional groups
Methodology
Pyridines
Online AccessGet full text

Cover

More Information
Summary:Herein, we report a highly effective homogeneous methodology for the N -alkylation of amines with primary and secondary alcohols using a Co( ii )-complex of an inverse triazolyl-pyridine ligand. The developed methodology tolerates various functional groups to produce the desired N -alkylated products in up to 98% yield. A number of control experiments establish that the developed methodology follows a hydrogen auto-transfer (HAT) pathway.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc01996b