Nanoparticle-driven biosensors for diagnosis of viral hepatitis

• Published in: TrAC, Trends in analytical chemistry (Regular ed.) Vol. 180; p. 117985
• Main Authors: Zhu, Chenggong, Xun, Zhen, Fu, Ruijie, Huang, Qunfang, Ou, Qishui, Xianyu, Yunlei, Liu, Can
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2024
• Subjects: Biomarker; Biosensor; Diagnosis; Nanoparticle; Viral hepatitis; Viral hepatitis; Biomarker; Diagnosis; Nanoparticle; Biosensor
• ISSN: 0165-9936
• DOI: 10.1016/j.trac.2024.117985

Rapid and accurate laboratory diagnosis are essential for the effective control of viral hepatitis. With the advances in nanotechnology, the application of nanoparticle-based biosensors for the diagnosis of viral hepatitis has attracted extensive attention. The excellent physicochemical properties of nanoparticles, such as extensive specific surface area, heightened surface energy, enhanced electrical conductivity, and facile size and structural modifiability, confer exceptional performance on biosensors. In this review, we summarize the latest advances in the field of laboratory diagnosis for viral hepatitis, focusing on the use of nanoparticle-based biosensors in the identification of viral biomarkers and liver function biomarkers. Additionally, we discuss current challenges and future prospects of nanoparticle-based biosensors in the diagnosis of viral hepatitis. [Display omitted] •This review offers a comprehensive overview of nanoparticle-based biosensors for diagnosing viral hepatitis.•The characteristics of nanoparticles, the sensing principles, and the signal readout mechanisms in biosensors are reviewed.•The current challenges of nanoparticle-based biosensors are discussed, and potential solutions are presented.