Photocatalytic C-H alkylation of coumarins mediated by triphenylphosphine and sodium iodide

Metal-and oxidant-free photocatalytic C-H alkylation of coumarins is developed in the presence of triphenylphosphine and sodium iodide under blue LEDs irradiation by using the easily available alkyl N-hydroxyphthalimide esters as the alkylation reagents. The metal-and oxidant-free decarboxylative C-...

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Bibliographic Details
Published inTetrahedron letters Vol. 96; pp. 153720 - 153723
Main Authors Gan, Xinyang, Wu, Shaofeng, Geng, Furong, Dong, Jianyu, Zhou, Yongbo
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 27.04.2022
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ETHERS
ARYLATION
Coumarins
Metal-and oxidant-free
Triphenylphosphine
Photocatalytic alkylation
DERIVATIVES
Sodium iodide
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Summary:Metal-and oxidant-free photocatalytic C-H alkylation of coumarins is developed in the presence of triphenylphosphine and sodium iodide under blue LEDs irradiation by using the easily available alkyl N-hydroxyphthalimide esters as the alkylation reagents. The metal-and oxidant-free decarboxylative C-H coupling protocol provides various 3-alkylated coumarins, as well as quinoxalinones, in satisfactory yields with excellent C-3 regioselectivity.(c) 2022 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.153720