Examination of the presence of periodontitis and gingivitis in rats with induced diabetes mellitus
Introduction. Diabetes mellitus (DM) is a state of chronic hyperglycemia that is a predisposing factor to caries, gingivitis, inflammation of periodontium, oral candidiasis, xerostomia and many other diseases of the oral cavity. Inflammation of the supporting tissue of the tooth is a chronic disease...
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Published in | Stomatološki glasnik Srbije Vol. 70; no. 3; pp. 131 - 137 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Serbian Medical Society - Dental Section, Belgrade
2023
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Subjects | |
Online Access | Get full text |
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Summary: | Introduction. Diabetes mellitus (DM) is a state of chronic hyperglycemia that
is a predisposing factor to caries, gingivitis, inflammation of
periodontium, oral candidiasis, xerostomia and many other diseases of the
oral cavity. Inflammation of the supporting tissue of the tooth is a chronic
disease that destroys the supporting structure of the tooth, i.e.
periodontal ligament and alveolar bone. The aim of this study was to examine
using histological analysis the presence of periodontitis and gingivitis in
rats with experimentally induced DM that were sacrificed after 14 and 30
days. Material and methods. The research was conducted on 42 Wistar rats. DM
in experimental animals was induced by the use of Alloxan intraperitoneally.
The first group (Exp_14) consisted of 16 rats in which DM was induced and
sacrificed after 14 days, the second group (Exp_30) consisted of 16 rats in
which DM was induced and they were sacrificed after 30 days, while the
control consisted of 10 healthy rats. Results. Periodontitis and gingivitis
in the first group of rats (Exp_14) were determined in 54.5% of cases, while
in the second group (Exp_30) in 88% of cases. In the control group no case
of periodontitis and gingivitis was recorded. A highly statistically
significant difference was found between the examined groups (Chi-square =
14.685; p < 0.001). Conclusion. In the group of rats with experimentally
induced DM that were sacrificed after 30 days, a significantly higher
incidence of periodontitis and gingivitis was found compared to the group of
rats that were sacrificed after 14 days. |
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ISSN: | 0039-1743 1452-3701 |
DOI: | 10.2298/SGS2303131K |