Hormone thyroïdienne et développement du cervelet : effets directs ou indirects ?

Abstract Thyroid hormone (T3) exerts an important influence on neurodevelopment, which can be analysed by using the postnatal development of rodent cerebellum as a model. T3 acts on all types of neuronal and glial cells, which express at least the TRα1 nuclear receptor, and, for some of them, the TR...

Full description

Saved in:
Bibliographic Details
Published inAnnales d'endocrinologie Vol. 72; no. 2; pp. 99 - 102
Main Authors Chatonnet, F, Fauquier, T, Picou, F, Guyot, R, Flamant, F
Format Journal Article Conference Proceeding
LanguageFrench
Published Paris Elsevier Masson SAS 2011
Masson
Subjects
Cerebellum
Cervelet
Endocrinology & Metabolism
Hormone thyroïdienne
Internal Medicine
Neurodevelopment
Neurodéveloppement
Nuclear receptor
Récepteur nucléaire
Sciences biologiques et medicales
Sciences biologiques fondamentales et appliquees. Psychologie
Thyroid hormone
Vertebres: endocrinologie
Hormone thyroïdienne
Cerebellum
Neurodéveloppement
Nuclear receptor
Cervelet
Neurodevelopment
Thyroid hormone
Récepteur nucléaire
Système nerveux central
Développement
Encéphale
Glande endocrine
Récepteur biologique
Thyroïde
Online AccessGet full text

Cover

More Information
Summary:Abstract Thyroid hormone (T3) exerts an important influence on neurodevelopment, which can be analysed by using the postnatal development of rodent cerebellum as a model. T3 acts on all types of neuronal and glial cells, which express at least the TRα1 nuclear receptor, and, for some of them, the TRβ1 isoform. However, as T3 also activates the secretion of neurotrophins, it can also affect cellular differentiation in an indirect manner. Ongoing experiments, based on mouse genetics and genome wide analysis of gene expression, provide a promising way to study the basic mechanisms of neurodevelopment. This review describes new mouse genetics models and recent advance in this field.
ISSN:0003-4266
DOI:10.1016/j.ando.2011.03.012