Photodynamic therapy for age-related macular degeneration

To evaluate short-term effects of single photodynamic therapy (PDT) for age-related macular degeneration (AMD) accompanied with choroidal neovascularization (CNV). We analyzed retrospectively the effects of single PDT for 20 patients (20 eyes) with CNV caused by AMD. Corrected visual acuity, fluores...

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Published inYanke xuebao Vol. 20; no. 3; p. 158
Main Authors Jin, Chenjin, Ge, Jian, Zhou, Shaobo, Chen, Huiyi, Zhong, Xiaojing, Jiang, Ruzhang, Chen, Lingyan, Chen, Lirong
Format Journal Article
LanguageEnglish
Published China 01.09.2004
Subjects
Aged
Choroidal Neovascularization - drug therapy
Choroidal Neovascularization - metabolism
Choroidal Neovascularization - pathology
Female
Fluorescein - metabolism
Fluorescein Angiography
Follow-Up Studies
Humans
Macular Degeneration - drug therapy
Male
Middle Aged
Photochemotherapy
Photosensitizing Agents - administration & dosage
Photosensitizing Agents - therapeutic use
Porphyrins - administration & dosage
Porphyrins - therapeutic use
Retrospective Studies
Tomography, Optical Coherence
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Summary:To evaluate short-term effects of single photodynamic therapy (PDT) for age-related macular degeneration (AMD) accompanied with choroidal neovascularization (CNV). We analyzed retrospectively the effects of single PDT for 20 patients (20 eyes) with CNV caused by AMD. Corrected visual acuity, fluorescein angiography (FA) and optic coherence tomography (OCT) were examined before and after PDT. All patients were followed up at least 3 months. At the end of 3-month follow-up, 5 eyes had vision progress, 15 eyes had vision stable and no eye had vision deterioration. Fluorescein angiography one week post PDT showed cessation of fluorescein leakage in 8 eyes with predominant classic CNV, and reduction of fluorescein leakage in 12 eyes with minimal classic CNV or occult CNV without classic component. At the 3-month following PDT fluorescein angiography showed fluorescein leakage reappeared in 4 of 8 eyes with predominant classic CNV. Among 12 eyes with minimal classic CNV or occult CNV without classic component, 9 eyes showed decreased or unchanged fluorescein leakage, 3 eyes had a progression of fluorescein leakage. Optic coherence tomography showed obvious recovery of serous sensory retinal detachment after PDT. PDT may occlude or inhibit CNV caused by AMD in short-term. No obvious side effects were noticed.
ISSN:1000-4432