Correlation between electrophysiological test and visual dysfunction in multiple sclerosis patients

Purpose Evaluate best corrected visual acuity (BCVA), contrast sensitivity (SC), pattern electroretinogram (pERG), multifocal electroretinogram (mfERG), and multifocal visual evoked potentials (mfVEP) in multiple sclerosis (MS) and compare with healthy controls. Methods Fifty‐eight eyes were include...

Full description

Saved in:
Bibliographic Details
Published inActa ophthalmologica (Oxford, England) Vol. 95; no. S259
Main Authors Vildades Palomar, E., Orduna Hospital, E., Ciprés, M., Obis, J., Rodrigo SanJuan, M.J., Satué Palacian, M., Garcia‐Martin, E.
Format Journal Article
LanguageEnglish
Published Malden Wiley Subscription Services, Inc 01.09.2017
Subjects
Acuity
Auditory evoked potentials
Electrophysiology
Evoked potentials
Latency
Multiple sclerosis
Neuritis
Optic neuritis
Psychophysics
Visual acuity
Visual evoked potentials
Visual perception
Online AccessGet full text

Cover

More Information
Summary:Purpose Evaluate best corrected visual acuity (BCVA), contrast sensitivity (SC), pattern electroretinogram (pERG), multifocal electroretinogram (mfERG), and multifocal visual evoked potentials (mfVEP) in multiple sclerosis (MS) and compare with healthy controls. Methods Fifty‐eight eyes were included: 14 of healthy controls and 44 of subjects with MS (of whom 17 presented a previous episode of optic neuritis). The BCVA ETDRS was recorded at 100% contrast, 2.5% and 1.25%, CS with CSV1000 test (at 3, 6, 9 and 12 cycles per degree) and Pelli Robson. The pERG, mfERG and mfVEP electrophysiology tests were performed with the Roland Consult's Reti‐port / scan device. Results Patients with MS showed a significant reduction of VA at 100% contrast (p = 0.013), 2.5% (p <0.001) and 1.25% (p = 0.008), CSV‐1000 was also affected at 3 (p = 0.017), 9 (p = 0.017), and 12 cycles per degree (p = 0.048), and also Pelli Robson (p <0.001). The mfERG showed in MS patients a significant affectation for amplitude and latency at the inferonasal and superonasal quadrants (p = 0.045 and 0.042 respectively), and the overall values of the mfPEV sown abnormalities at N1 and P1 amplitudes (p = 0.019 and p = 0.039, respectively). Conclusions Patients with MS have a clear impairment of visual function in both psychophysical and electrophysiological tests.
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2017.0T035