Influence of the Changes in the Bone Mineral Density on the Guided Bone Regeneration Using Bioinspired Grafts: A Systematic Review and Meta-analysis

Nowadays, developing bone tissue grafts is the key to regenerative medicine. Different materials like hydroxyapatite (HAp) have been proven to guide bone regeneration. However, their design is still lacking since most do not consider the patient's requirements. HAps can be synthetic or natural,...

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Bibliographic Details
Published inBiomedical Materials & Devices Vol. 1; no. 1; pp. 162 - 178
Main Authors Castillo-Paz, Angelica M., Correa-Piña, Brandon A., Martinez-Hernandez, Harol D., Gomez-Vazquez, Omar M., Cañon-Davila, Dorian F., Zubieta-Otero, Luis F., Londoño-Restrepo, Sandra M., Perez-Torrero, Esther, Rodriguez-Garcia, Mario E.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2023
Subjects
Biomaterials
Biomedical Engineering/Biotechnology
Chemistry and Materials Science
Materials Engineering
Materials Science
Review
Bone mineral content
Bone mineral density
Hydroxyapatite
Grafts
Minerals
Commercial grafts
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Summary:Nowadays, developing bone tissue grafts is the key to regenerative medicine. Different materials like hydroxyapatite (HAp) have been proven to guide bone regeneration. However, their design is still lacking since most do not consider the patient's requirements. HAps can be synthetic or natural, and their Ca/P ratio varies depending on the reagents for the synthesis and the biological sources. Usually, synthetic HAps are designed to have a 1.67 Ca/P ratio, but Ca/P and Mg/P ratios naturally change throughout life for different reasons, such as age, gender, lifestyle, genetics, physical activity, body weight, and diet, accompanied by changes in bone mineral density (BMD) and bone mineral content (BMC). Until now, there is not enough information about mammal bone changes based on these ratios, BMD, BMC at different life stages, and people's gender. To face this lack of knowledge, animal models such as rats can be used to identify requirements for proper bone grafting materials based on life stages since they consider the age range and gender. Findings indicate that BMD, BMC, Ca/P, and Mg/P change as a function of the age and gender of rats. Thus, it suggests that the grafts need a personalized development considering these parameters.
ISSN:2731-4812
2731-4820
DOI:10.1007/s44174-022-00026-z