Zeolite-Loaded Hydrogels as Wound pH-Modulating Dressings for Diabetic Wound Healing

Wound pH has emerged as a promising therapeutic target in diabetic foot ulcers (DFU). Here, we aimed to develop a microparticle-loaded hydrogel for pH modulation in wound fluid. In a screen of polymeric and inorganic microparticles, zeolites were identified as pH-modulating microparticles. Zeolites...

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Bibliographic Details
Published inACS applied bio materials
Main Authors Tricou, Léo-Paul, Guirguis, Natalie, Cherifi, Katia, Matoori, Simon
Format Journal Article
LanguageEnglish
Published United States 23.05.2024
Subjects
buffer capacity
alginate hydrogel
pH modulation
diabetic wound healing
zeolite microparticles
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Summary:Wound pH has emerged as a promising therapeutic target in diabetic foot ulcers (DFU). Here, we aimed to develop a microparticle-loaded hydrogel for pH modulation in wound fluid. In a screen of polymeric and inorganic microparticles, zeolites were identified as pH-modulating microparticles. Zeolites were encapsulated in a calcium cross-linked alginate hydrogel, a biocompatible matrix clinically used as a wound dressing. This hydrogel potently neutralized hydroxide ions in serum-containing simulated wound fluid. These findings encourage a further development of this pH-modulating device as a molecular therapeutic system for DFUs.
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ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.4c00332