Xylose Incorporated in Unsymmetrical Gold(I) N-Heterocyclic Carbene Complexes: Synthesis, Characterization and Antibacterial Activity

A series of Au(I) complexes containing unsymmetrical N-heterocyclic carbene (imidazolylidene and benzimidazolylidene) functionalized with a xyloside group and an alkyl moiety (methyl and mesityl) was prepared using efficient procedures from D-xylose. Their characterization was carried out in solutio...

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Published inChemMedChem p. e202400245
Main Authors Pascual, Laura M H, Colin, Marius, Mohamadou, Aminou, Kowandy, Christelle, Plantier-Royon, Richard, Gatard, Sylvain
Format Journal Article
LanguageEnglish
Published Germany 24.09.2024
Subjects
N-heterocyclic carbene
Xylose
Gold
Antibacterial
Complexes
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Summary:A series of Au(I) complexes containing unsymmetrical N-heterocyclic carbene (imidazolylidene and benzimidazolylidene) functionalized with a xyloside group and an alkyl moiety (methyl and mesityl) was prepared using efficient procedures from D-xylose. Their characterization was carried out in solution by multinuclear NMR, HR-MS spectrometry and cyclic voltammetry, as well as in the solid state by means of single crystal X-ray diffraction analysis for two of them. Evaluation of their ability to inhibit bacterial growth showed a preference for a Gram-positive strain, Staphylococcus aureus, over a Gram-negative strain, Pseudomonas aeruginosa.
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ISSN:1860-7179
1860-7187
1860-7187
DOI:10.1002/cmdc.202400245