Sympatholytic effect of intravascular ATP is independent of nitric oxide, prostaglandins, Na + /K + ‐ATPase and K IR channels in humans

Intravascular ATP attenuates sympathetic vasoconstriction (sympatholysis) similar to what is observed in contracting skeletal muscle of humans, and may be an important contributor to exercise hyperaemia. Similar to exercise, ATP‐mediated vasodilatation occurs via activation of inwardly rectifying po...

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Published inThe Journal of physiology Vol. 595; no. 15; pp. 5175 - 5190
Main Authors Hearon, Christopher M., Richards, Jennifer C., Racine, Mathew L., Luckasen, Gary J., Larson, Dennis G., Joyner, Michael J., Dinenno, Frank A.
Format Journal Article
LanguageEnglish
Published England 01.08.2017
Subjects
Adenosine Triphosphate - physiology
Adult
Brachial Artery - physiology
Female
Forearm - blood supply
Forearm - physiology
Humans
Male
Nitric Oxide - physiology
Potassium Channels, Inwardly Rectifying - physiology
Prostaglandins - physiology
Regional Blood Flow
Sodium-Potassium-Exchanging ATPase - physiology
Vasoconstriction - physiology
Young Adult
blood flow control
sympatholysis
adenosine triphosphate
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Summary:Intravascular ATP attenuates sympathetic vasoconstriction (sympatholysis) similar to what is observed in contracting skeletal muscle of humans, and may be an important contributor to exercise hyperaemia. Similar to exercise, ATP‐mediated vasodilatation occurs via activation of inwardly rectifying potassium channels (K IR ), and synthesis of nitric oxide (NO) and prostaglandins (PG). However, recent evidence suggests that these dilatatory pathways are not obligatory for sympatholysis during exercise; therefore, we tested the hypothesis that the ability of ATP to blunt α 1 ‐adrenergic vasoconstriction in resting skeletal muscle would be independent of K IR , NO, PGs and Na + /K + ‐ATPase activity. Blockade of K IR channels alone or in combination with NO, PGs and Na + /K + ‐ATPase significantly reduced the vasodilatatory response to ATP, although intravascular ATP maintained the ability to attenuate α 1 ‐adrenergic vasoconstriction. This study highlights similarities in the vascular response to ATP and exercise, and further supports a potential role of intravascular ATP in blood flow regulation during exercise in humans.
ISSN:0022-3751
1469-7793
DOI:10.1113/JP274532