Five New Furostanol Glycosides from the Fruits of Tribulus terrestris with NO Production Inhibitory Activity

Eight furostanol glycosides including five undescribed compounds, named tribufurostanosides A-E (1-5), and three known ones (6-8) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR-ESI-MS, 1D-, and 2D-NMR spectra. Furostanols 1-8 significa...

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Published inChemistry & biodiversity Vol. 21; no. 9; p. e202401273
Main Authors Kiem, Phan Van, Van Quoc, Nguyen, Tai, Bui Huu, Yen, Pham Hai, Hoang, Nguyen Huy, Hang, Dan Thi Thuy, Huong, Phan Thi Thanh, Bang, Ngo Anh, Dung, Duong Thi, Trang, Do Thi, Giang, Le Duc
Format Journal Article
LanguageEnglish
Published Switzerland 03.06.2024
Subjects
NO inhibitory activity
furostanol glycoside
Tribulus terrestris
Zygophyllaceae
tribufurostanosides A-E
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Summary:Eight furostanol glycosides including five undescribed compounds, named tribufurostanosides A-E (1-5), and three known ones (6-8) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR-ESI-MS, 1D-, and 2D-NMR spectra. Furostanols 1-8 significantly inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC50 values ranging from 14.2 to 64.7 µM, compared to that of the positive control compound, dexamethazone (IC50 13.6 µM).
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ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202401273