MPC-10 Prognostic analysis in IDH mutant astrocytoma patient with CDKN2A/B homozygous deletion

Abstract background: IDH mutant astrocytoma has good prognosis compared with IDH wildtype one. In IDH mutant astrocytoma, However, patients with CDKN2A/B homozygous deletion (HD) are worse prognosis than non CDKN2A/B HD. Here we analyzed the prognosis of glioma patients identified with CDKN2A/B HD i...

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Published inNeuro-oncology advances Vol. 3; no. Supplement_6; p. vi17
Main Authors Yanagisawa, Shunsuke, Satomi, Kaishi, Miyakita, Yasuji, Ohno, Makoto, Takahashi, Masamichi, Tamura, Yukie, Kawachi, Daisuke, Kikuchi, Miyu, Kitahara, Mai, Matushita, Yuko, Yoshida, Akihiko, Ichimura, Koichi, Narita, Yoshitaka
Format Journal Article
LanguageEnglish
Published US Oxford University Press 06.12.2021
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astrocytoma
IDH mutation
CDKN2A/B homozygous deletion
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Summary:Abstract background: IDH mutant astrocytoma has good prognosis compared with IDH wildtype one. In IDH mutant astrocytoma, However, patients with CDKN2A/B homozygous deletion (HD) are worse prognosis than non CDKN2A/B HD. Here we analyzed the prognosis of glioma patients identified with CDKN2A/B HD in our hospital. method: There were 62 cases, and female was 26. Mean age of all cases was 41.2 and median age was 38. In IDH gene status, R132H was 59 cases (95.2%), R172K 2 (3.2%) and R132S 1 (1.6%). All 62 cases were TERT wildtype. CDKN2A/B HD were 12 cases (19.4%). In log-rank test, the group of CDKN2A/B HD was poor prognosis than non HD. In astrocytoma grade 3, CDKN2A/B HD had significantly poor prognosis (p=0.002). In Cox proportional hazard model analysis, CDKN2A/B HD was effective predictive prognostic factor as well as age and grading (p=0.03). discussion/conclusion: We showed that CDKN2A/B HD was good predictive prognostic factor in IDH mutant astrocytoma.
ISSN:2632-2498
2632-2498
DOI:10.1093/noajnl/vdab159.064