Biosurfactant complexed with arginine has antibiofilm activity against methicillin-resistant Staphylococcus aureus

• Published in: Future microbiology Vol. 19; no. 8; p. 667
• Main Authors: Dias Barroso, Fatima Daiana, da Silva, Lisandra Juvêncio, Queiroz, Helaine Almeida, do Amaral Valente Sá, Lívia Gurgel, da Silva, Anderson Ramos, da Silva, Cecília Rocha, de Andrade Neto, João Batista, Cavalcanti, Bruno Coêlho, de Moraes, Manoel Odorico, Pinazo, Aurora, Pérez, Lourdes, Nobre Júnior, Hélio Vitoriano
• Format: Journal Article
• Language: English
• Published: England 23.05.2024
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Arginine - chemistry; Arginine - pharmacology; Biofilms - drug effects; Biofilms - growth & development; Drug Synergism; Glycolipids - chemistry; Glycolipids - pharmacology; Humans; Methicillin-Resistant Staphylococcus aureus - drug effects; Microbial Sensitivity Tests; Oxacillin - pharmacology; Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcal Infections - prevention & control; Surface-Active Agents - chemistry; Surface-Active Agents - pharmacology; medical catheter; surfactants; biofilms; Staphylococcus aureus; MRSA
• ISSN: 1746-0921
• DOI: 10.2217/fmb-2023-0271

The present study investigated the antimicrobial effectiveness of a rhamnolipid complexed with arginine (RLMIX_Arg) against planktonic cells and biofilms of methicillin-resistant (MRSA). Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol: M07-A10, checkerboard test, biofilm in plates and catheters and flow cytometry were used. RLMIX_Arg has bactericidal and synergistic activity with oxacillin. RLMIX_Arg inhibits the formation of MRSA biofilms on plates at sub-inhibitory concentrations and has antibiofilm action against MRSA in peripheral venous catheters. Catheters impregnated with RLMIX_Arg reduce the formation of MRSA biofilms. RLMIX_Arg exhibits potential for application in preventing infections related to methicillin-resistant biofilms.