Iodine(III) reagents for the aromatic functionalization with inorganic groups

• Published in: Tetrahedron Vol. 166; p. 134203
• Main Authors: Barrera-Nava, Miriam P., Segura-Quezada, Luis A., Ibarra-Gutiérrez, Jaime G., Chávez-Rivera, Rubén, Ortiz-Alvarado, Rafel, Solorio-Alvarado, César R.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 17.10.2024
• Subjects: Inorganic functionalization of arenes; Iodine (III) reagents; Oxidative aromatic halogenation; Iodine (III) reagents; Oxidative aromatic halogenation; Inorganic functionalization of arenes
• ISSN: 0040-4020
• DOI: 10.1016/j.tet.2024.134203

Iodine(III) reagents have gained importance in organic synthesis due to their strong oxidative properties in addition to several advantages over other related such as, non-toxic, green, easy to handle and in general safe for using. These characteristics become them useful tools and represent relevant alternatives to procedures which involves harsh and/or hazardous reaction conditions. They are versatile oxidants that has been largely used in the functionalization of a broad variety of aromatic nucleus, resulting in the introduction of several groups, including in the most general classification, organic and inorganics. In this sense, the metal-free arylation mediated by iodine(III) reagents is the most reported issue in the literature. Nevertheless, other relevant inorganic functionalities were also introduced. Herein, we review the most important procedures described to date for the aromatic functionalization with inorganic groups such as halogens, as well as the nitro-, azido, cyano-, sulfur- and selenium groups, under the iodine(III) chemistry. [Display omitted]