A benzothiazole-based fluorescent probe for distinguishing and bioimaging of Hg 2+ and Cu 2
A new benzothiazole-based fluorescent probe 2-(benzo[d]thiazol-2-yl)-4-(1,3- dithian-2-yl)phenol (BT) with two different reaction sites, a thioacetal group (site 1 for Hg ), and O and N atoms of the benzothiazole dye (site 2 for Cu ), was designed and synthesized. The probe BT showed ratiometric flu...
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Published in | Analytica chimica acta Vol. 954; pp. 97 - 104 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
01.02.2017
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Subjects | |
Online Access | Get full text |
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Summary: | A new benzothiazole-based fluorescent probe 2-(benzo[d]thiazol-2-yl)-4-(1,3- dithian-2-yl)phenol (BT) with two different reaction sites, a thioacetal group (site 1 for Hg
), and O and N atoms of the benzothiazole dye (site 2 for Cu
), was designed and synthesized. The probe BT showed ratiometric fluorescent response to Hg
and fluorescence quenching behavior to Cu
, which induces naked-eye fluorescent color changes from green to blue and colorless, respectively. Moreover, it displayed highly sensitivity and selectivity toward Hg
and Cu
without interference from other metal ions. The sensing mechanisms were also confirmed by
H NMR titration, mass spectrum and Job's plot analyses. Finally, probe BT was successfully used for fluorescent imaging of Hg
and Cu
in living cells, demonstrating its potential applications in biological science. |
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ISSN: | 0003-2670 1873-4324 |
DOI: | 10.1016/j.aca.2016.11.044 |