FIP1L1/PDGFRA (F/P) Fusion Gene Induces Eosinophil Development, Activation, and Survival Synergistically with SCF and IL-5

Methods F/P- or vector control-transduced bone marrow hematopoietic stem cell/progenitors (BM-HSC/P) were cultured on FBMD-1-, a hematopoiesis-supportive stromal cell line, conditioned media (CM) or SCF and transferred to IL-5-containing methylcellulose after 3 weeks of culture for CFU-Eosinophil as...

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Published inJournal of allergy and clinical immunology Vol. 121; no. 2; p. S216
Main Authors Yamada, Y, Cancelas, J.A, McBride, M, Sanchez-Aguilera, A, Williams, D.A, Rothenberg, M.E
Format Journal Article
LanguageEnglish
Published St. Louis Mosby, Inc 01.02.2008
Elsevier Limited
Subjects
Allergy and Immunology
Medical research
Migration
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Summary:Methods F/P- or vector control-transduced bone marrow hematopoietic stem cell/progenitors (BM-HSC/P) were cultured on FBMD-1-, a hematopoiesis-supportive stromal cell line, conditioned media (CM) or SCF and transferred to IL-5-containing methylcellulose after 3 weeks of culture for CFU-Eosinophil assay.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2007.12.809