Synthesis of 6-chloronicotinates of steroidal 3β,5α,6β-triols and 3β,5-dihydroxy-6-ketones

New esters of 3β,5α,6β-trihydroxysteroids and 3β,5-dihydroxy-6-ketosteroids containing 6-chloropyridine groups characteristic of the alkaloid epibatidine were synthesized by acylation with 6-chloronicotinoylchloride.

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Bibliographic Details
Published inChemistry of natural compounds Vol. 45; no. 2; pp. 200 - 204
Main Authors Kovganko, N. V, Chernov, Yu. G, Sokolov, S. N, Kashkan, Zh. N, Survilo, V. L
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 2009
Springer US
Subjects
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
synthesis
6-chloronicotinoylchloride
3β,5α,6β-trihydroxysteroids
6-chloronicotinates
3β,5-dihydroxy-6-ketosteroids
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Summary:New esters of 3β,5α,6β-trihydroxysteroids and 3β,5-dihydroxy-6-ketosteroids containing 6-chloropyridine groups characteristic of the alkaloid epibatidine were synthesized by acylation with 6-chloronicotinoylchloride.
Bibliography:http://dx.doi.org/10.1007/s10600-009-9265-6
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-009-9265-6