Pinnothin™ suppresses appetite in overweight women

• Published in: Appetite Vol. 49; no. 1; p. 330
• Main Authors: Scott, C., Pasman, W., Heimerikx, J., Rubingh, C., van den Berg, R., O’Shea, M., Gambelli, L., Hendriks, H., Mennen, L., Einerhand, A.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.07.2007
• Subjects: Olea; Pinus koraiensis
• DOI: 10.1016/j.appet.2007.03.186
• ISSN: 0195-6663

Controlling food intake by suppressing appetite can potentially be one of the principal approaches to preventing weight gain and obesity. A major gut hormone involved in appetite control is cholecystokinin (CCK), where previous experiments showed that polyunsaturated fatty acids (PUFAs) derived from Korean pine nuts (Pinus koraiensis) PinnoThin™ induces high amounts of CCK release by STC-1 enteroendocrine cells. This study investigates the effects of PinnoThin™ on appetite sensations and appetite-regulating hormones in humans. A randomized, cross-over, placebo-controlled, double-blind study was performed with 18 overweight post-menopausal women (BMI=25–30 kg/m 2) receiving capsules with 3 g PinnoThin™ or olive oil (placebo) with a light breakfast. At 0, 30, 60, 90, 120, 180 and 240 min following supplementation blood samples were taken for analyses of appetite suppressing hormones CCK and glucagon-like peptide-1 (GLP-1). Appetite sensations were evaluated by using visual analogue scales. PinnoThin™ significantly induced CCK after 30 min and GLP-1 after 60 min relative to placebo. Over a period of 4 h the total amount of plasma CCK and GLP-1 in response to PinnoThin™ was 60% ( P<0.0001) and 25% ( P<0.05) higher than in response to placebo, respectively. PinnoThin™ affected appetite sensations during the 4 hours after intake. Especially, at 30 minutes the “desire to eat” and the “prospective food intake” scores were, 29% and 36% lower relative to placebo, respectively. PinnoThin™ significantly increased CCK and GLP-1 levels and affected appetite sensations, suggesting that PinnoThin™ may affect food intake. Further clinical work aimed at understanding the role of PinnoThin™ and satiety will be discussed.