Pinnothin™ suppresses appetite in overweight women
Controlling food intake by suppressing appetite can potentially be one of the principal approaches to preventing weight gain and obesity. A major gut hormone involved in appetite control is cholecystokinin (CCK), where previous experiments showed that polyunsaturated fatty acids (PUFAs) derived from...
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Published in | Appetite Vol. 49; no. 1; p. 330 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.07.2007
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Subjects | |
Online Access | Get full text |
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Summary: | Controlling food intake by suppressing appetite can potentially be one of the principal approaches to preventing weight gain and obesity. A major gut hormone involved in appetite control is cholecystokinin (CCK), where previous experiments showed that polyunsaturated fatty acids (PUFAs) derived from Korean pine nuts
(Pinus koraiensis) PinnoThin™ induces high amounts of CCK release by STC-1 enteroendocrine cells. This study investigates the effects of PinnoThin™ on appetite sensations and appetite-regulating hormones in humans. A randomized, cross-over, placebo-controlled, double-blind study was performed with 18 overweight post-menopausal women (BMI=25–30
kg/m
2) receiving capsules with 3
g PinnoThin™ or olive oil (placebo) with a light breakfast. At 0, 30, 60, 90, 120, 180 and 240
min following supplementation blood samples were taken for analyses of appetite suppressing hormones CCK and glucagon-like peptide-1 (GLP-1). Appetite sensations were evaluated by using visual analogue scales. PinnoThin™ significantly induced CCK after 30
min and GLP-1 after 60
min relative to placebo. Over a period of 4
h the total amount of plasma CCK and GLP-1 in response to PinnoThin™ was 60% (
P<0.0001) and 25% (
P<0.05) higher than in response to placebo, respectively. PinnoThin™ affected appetite sensations during the 4 hours after intake. Especially, at 30 minutes the “desire to eat” and the “prospective food intake” scores were, 29% and 36% lower relative to placebo, respectively. PinnoThin™ significantly increased CCK and GLP-1 levels and affected appetite sensations, suggesting that PinnoThin™ may affect food intake. Further clinical work aimed at understanding the role of PinnoThin™ and satiety will be discussed. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0195-6663 1095-8304 |
DOI: | 10.1016/j.appet.2007.03.186 |