Cord Blood Hemopoietic Progenitor Cell Toll-Like Receptor Expression and Function: A Mechanism Underlying Allergic Inflammation in Early Life

Neonatal immune responses to environmental stimuli, mediated via TLR, may determine the development of atopy in childhood. Since hemopoietic mechanisms are involved in development and maintenance of allergic inflammation, we investigated alterations in progenitor expression and differentiation profi...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 125; no. 2; p. AB105
Main Authors Reece, P, Crawford, L, Baajtes, A, Cyr, M, Sehmi, R, Denburg, J.A
Format Journal Article
LanguageEnglish
Published St. Louis Mosby, Inc 01.02.2010
Elsevier Limited
Subjects
Allergy and Immunology
Blood
Cytokines
Medical research
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Summary:Neonatal immune responses to environmental stimuli, mediated via TLR, may determine the development of atopy in childhood. Since hemopoietic mechanisms are involved in development and maintenance of allergic inflammation, we investigated alterations in progenitor expression and differentiation profiles after stimulation with TLR agonists.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.415