Strain-dependent Influences On C-kit Function Alter The Mast Cell Phenotype Of Hyperresponsive A/J Mice

Compared with C57BL/6 control mice, naïve A/J mice exhibit increased responsiveness to inhaled methacholine that is abrogated by the introduction of the W/v mutation into the A/J background) We sought to determine if A/J mice exhibited an aberrant mast cell phenotype.

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 127; no. 2; p. AB131
Main Authors Chong, H.J, Cozzi, E, Lundquist, A, Boyce, J, Beier, D
Format Journal Article
LanguageEnglish
Published St. Louis Mosby, Inc 01.02.2011
Elsevier Limited
Subjects
Allergy and Immunology
Genotype & phenotype
Medical research
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Summary:Compared with C57BL/6 control mice, naïve A/J mice exhibit increased responsiveness to inhaled methacholine that is abrogated by the introduction of the W/v mutation into the A/J background) We sought to determine if A/J mice exhibited an aberrant mast cell phenotype.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.12.523