U-shaped association between pan-immune-inflammation value and periodontitis: NHANES 2009-2014

• Published in: Journal of periodontology (1970)
• Main Authors: Zhou, Huan, Zhang, Shusen, Miao, Di, Cao, Ruoyan
• Format: Journal Article
• Language: English
• Published: United States 06.08.2024
• Subjects: cross‐sectional study; NHANES; pan‐immune‐inflammation value; periodontitis
• ISSN: 1943-3670
• DOI: 10.1002/JPER.24-0318

This study aimed to investigate the relationship between the pan-immune-inflammation value (PIV) and periodontitis based on a large national survey. In the present cross-sectional study, data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009-2014, which included a total of 10,300 participants. The categorization of periodontitis was based on the 2017 classification scheme. The PIV was determined using the formula: (neutrophils count × monocyte count × platelet count)/lymphocytes count. Restricted cubic spline and weighted multivariable logistic regression analyses were employed to evaluate the associations between the PIV with periodontitis. The associations between PIV and stage III/IV periodontitis followed a U-shaped pattern (P  < 0.001). The risk of developing stage III/IV periodontitis showed an increasing trend among participants in the first quartile (odds ratio [OR] = 1.21; 95% confidence interval [CI]: 1.01-1.46), third quartile (OR = 1.34; 95% CI: 1.11-1.61), and fourth quartile (OR = 1.47; 95% CI: 1.25-1.73) compared to those in the second quartile. Subgroup analysis indicated stronger associations of PIV with periodontitis in males (OR  = 1.72, 95% CI: 1.36-2.18) and individuals with hypertension (OR  = 1.78, 95% CI: 1.38-2.28) with significant interactions (P  < 0.05). There is a U-shaped association between PIV and stage III/IV periodontitis, which suggests a potential adjunctive treatment strategy for periodontitis. Higher PIV values were found to have a stronger correlation with stage III/IV periodontitis in males and individuals with hypertension. Further prospective trials are needed to confirm the validity of our results. A U-shaped association exists between the pan-immune inflammation value and periodontitis in US adults, suggesting that maintaining a moderate immune inflammation response is crucial for periodontal health.