Alterations in reproductive tissue prostaglandins E and F, 6-keto-prostaglandin F1 alpha and thromboxane B2 with gestational age in the rat
Prostaglandins (PGs) are thought to have an important function in the initiation and/or propagation of parturition. To define the relationship of individual PGs to one another and compare their alterations with gestational age, PGF, PGE, 6-keto-PGF1 alpha (6KF) and thromboxane B2 (TxB2) were measure...
Saved in:
Published in | Biology of reproduction Vol. 27; no. 5; pp. 1207 - 1215 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Society for the Study of Reproduction
01.12.1982
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Prostaglandins (PGs) are thought to have an important function in the initiation and/or propagation of parturition. To define
the relationship of individual PGs to one another and compare their alterations with gestational age, PGF, PGE, 6-keto-PGF1
alpha (6KF) and thromboxane B2 (TxB2) were measured in uterine and placental tissue and uterine venous plasma of rats at Days
15, 18, 19, 20, and 21 of pregnancy and at delivery (Day 21 1/2). In addition, concomitant measurements of peripheral plasma
estradiol (E2), estrone (E1) and progesterone (P) and pituitary oxytocin (OT) content, putative regulators and/or modulators
of PG metabolism, were determined. Significant enhancements (P less than 0.05) in uterine 6KF, TxB2, PGF and PGE concentrations
(ng/mg DNA) were detected by Day 20 compared to Day 15 of pregnancy and further dramatic increases were found on Day 21 and
at delivery. Although uterine 6KF was present in the highest concentrations, PGF showed the greatest increment from Day 15
to delivery. No alterations in uterine venous plasma PGE or PGF concentration were found with gestational age but 6KF and
TxB2 showed significant increases at delivery. The placental concentrations of PGs were approximately 1/50 of uterine tissue.
Placental PGE and PGF concentrations (ng/mg DNA) increased only slightly at delivery but the augmentation in 6KF and TxB2
levels were of greater magnitude. Significant increases in E2 and E1 with reciprocal decreases in P occurred on Day 21 of
pregnancy. In contrast, pituitary OT content showed no alterations at any of the days examined. These results are consonant
with the hypothesis that uterine PGs have an important function in parturition and uterine-placental physiology, and suggest
that an increasing estrogen/P ratio at the end of pregnancy is related to enhanced uterine PG levels. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0006-3363 1529-7268 |
DOI: | 10.1095/biolreprod27.5.1207 |