Reconstitution of a corneal endothelium by intracameral injection of cultured endothelial cells

The only currently available treatment for irreversible corneal endothelial failure is allo‐transplantation, which is overshadowed by optical distortion of the posterior surface, postoperative donor corneal endothelial cells attrition and risk of rejection. Assessment of the in vivo functionality of...

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Bibliographic Details
Published inActa ophthalmologica (Oxford, England) Vol. 92; no. s253
Main Authors BRUNETTE, I, BOSTAN, C, THERIAULT, M, FORGET, K, PROULX, S
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.09.2014
Wiley Subscription Services, Inc
Subjects
Cornea
Endothelium
Ophthalmology
Transplants & implants
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Summary:The only currently available treatment for irreversible corneal endothelial failure is allo‐transplantation, which is overshadowed by optical distortion of the posterior surface, postoperative donor corneal endothelial cells attrition and risk of rejection. Assessment of the in vivo functionality of a corneal endothelium reconstituted by the injection of corneal endothelial cells in the anterior chamber of an endothelial deficiency model allows to consider cell‐injection as a possible therapy for corneal endotheliopathies.
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2014.3433.x