Rapid Desensitization after a Type I Hypersensitivity Reaction to Ceftazidime/ Avibactam

Frequent antibiotic use increases the risk of multidrug-resistant pathogen formation and hypersensitivity to antibiotics, including Type I hypersensitivity reactions. We present a case of the first successful induction of tolerance procedure for the antibiotic ceftazidime/ avibactam. The patient dev...

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Bibliographic Details
Published inFederal practitioner Vol. 39; no. 2; pp. 94 - 96
Main Authors Coop, Col Christopher A, Berg, Maj Joshua R
Format Journal Article
LanguageEnglish
Published United States Frontline Medical Communications Inc 01.02.2022
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Summary:Frequent antibiotic use increases the risk of multidrug-resistant pathogen formation and hypersensitivity to antibiotics, including Type I hypersensitivity reactions. We present a case of the first successful induction of tolerance procedure for the antibiotic ceftazidime/ avibactam. The patient developed immediate generalized urticaria and flushing on his first dose of ceftazidime/avibactam. He was able to tolerate a 12-step desensitization procedure that resulted in the clearance of his infection. Drug desensitization procedures are useful for patients with adverse drug reactions in which optimal alternatives are not available. This is the first case report demonstrating a successful rapid induction of tolerance for the antibiotic ceftazidime/avibactam.
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ISSN:1078-4497
1945-337X
DOI:10.12788/fp.0220