Tyrosine protein kinase Tec is involved in the pathogenesis of severe acute pancreatitis associated lung injury in mice

Method: C57BL/6 were randomly assigned to 1)severe acute pancreatitis associated lung injury(APALI)group, established by 7 injections of caerulein (ip,50μg/kg) at hourly interval followed by once injection of lipopolysaccharide(ip,10mg/kg); 2)control group, injected with normal saline only; and 3)i...

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Published inPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 16; no. 1; p. S20
Main Authors Yang, J, Wang, H.K, Li, L.X, Ren, H.B
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier India Pvt Ltd 01.01.2016
Elsevier Limited
Subjects
Endocrinology & Metabolism
Gastroenterology and Hepatology
Kinases
Pancreas
Pathogenesis
Proteins
Rodents
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Summary:Method: C57BL/6 were randomly assigned to 1)severe acute pancreatitis associated lung injury(APALI)group, established by 7 injections of caerulein (ip,50μg/kg) at hourly interval followed by once injection of lipopolysaccharide(ip,10mg/kg); 2)control group, injected with normal saline only; and 3)intervention group, treated with LFM-A13 (leflunomide metabolite analog) based on group one.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2015.12.067