Moonlighting Effects of Pyruvate Kinase M2 in Chronic Liver Diseases

Hepatic diseases have constituted a significant global problem for over two decades, numerous factors contribute to these diseases, and most eventually result in hepatocellular carcinoma. A particular pivotal factor responsible for hepatic diseases is the abnormal functioning of various metabolic pr...

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Bibliographic Details
Published inGene expression Vol. 22; no. 3; pp. 250 - 257
Main Authors Jadhav, Madhav, Sharma, Shailendra, Kalmegh, Vaishnavi, Kapoor, Saumya, Shard, Amit
Format Journal Article
LanguageEnglish
Published Sugar Land Xia & He Publishing 01.09.2023
Subjects
Abnormalities
Adenosine
Alcohol
Carcinogens
Cell growth
Endocrine system
Epidermal growth factor
Genes
Glucose
Glycolysis
Hepatitis
Hepatocellular carcinoma
Inflammation
Kinases
Liver cancer
Liver cirrhosis
Liver diseases
Medical prognosis
Metabolism
Metastasis
Phosphorylation
Proteins
Pyruvate kinase
Pyruvic acid
Tumors
Viral infections
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Summary:Hepatic diseases have constituted a significant global problem for over two decades, numerous factors contribute to these diseases, and most eventually result in hepatocellular carcinoma. A particular pivotal factor responsible for hepatic diseases is the abnormal functioning of various metabolic processes. Pyruvate kinase is a crucial regulator of the glycolytic pathway, and overexpression of pyruvate kinase isoform M2 (PKM2) has been observed with various hepatic abnormalities due to genetic malfunctioning and other contributing factors. The present scenario for diagnosing and treating hepatic diseases includes surgery and immunosuppressant therapies. Kinase modulation may also be a potential therapeutic measure for rectifying hepatic diseases, and this can serve as a potential approach. This review summarizes the malfunctions and significance of PKM2 regulation and explores the potential of PKM2 as a target for treating hepatic abnormalities.
ISSN:1052-2166
1555-3884
DOI:10.14218/GE.2023.00038