Corticotropin-releasing hormone type 2 receptor deficiency impairs pancreatic function in a sex-specific manner

Intravenous delivery of adeno-associated virus encoding urocortin2 (AAV.Ucn2) normalized blood glucose in high fat diet (HFD) and db/db mouse models of type II diabetes. Masson’s trichrome staining revealed fibrotic and highly vascular islets in Crhr2-/- than WT male mice, whereas female Crhr2-/- mi...

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Published inPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 17; no. 3; p. S8
Main Authors Bhargava, Aditi, Hagiwara, Shinichiro, Puri, Sapna, Hebrok, Matthias, Szot, Gregory, Hasdemir, Burcu, Paruthiyil, Sreenivasan
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier B.V 01.07.2017
Elsevier Limited
Subjects
Corticotropin-releasing hormone
Diabetes
Endocrinology & Metabolism
Gastroenterology and Hepatology
Insulin
Metabolic disorders
Pancreas
Pancreas transplantation
Rodents
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Summary:Intravenous delivery of adeno-associated virus encoding urocortin2 (AAV.Ucn2) normalized blood glucose in high fat diet (HFD) and db/db mouse models of type II diabetes. Masson’s trichrome staining revealed fibrotic and highly vascular islets in Crhr2-/- than WT male mice, whereas female Crhr2-/- mice showed a milder phenotype.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2017.05.026