Visible‐Light‐Mediated Synthesis of Bicalutamide by Regioselective Hydroxysulfonylation of Acrylamides

Abstract Synthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N ‐arylacrylamide is described. This approach involves a one‐pot hydroxysulfonylation reaction through a photocatalytic redox process. The use of Na 2 Eosin Y as photocatalyst and blue lig...

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Bibliographic Details
Published inEuropean journal of organic chemistry Vol. 26; no. 37
Main Authors Zurro, Mercedes, Torres‐Oya, Sergio, Merino, Estíbaliz
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 02.10.2023
Subjects
Photocatalysis
Regioselectivity
Synthesis
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Summary:Abstract Synthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N ‐arylacrylamide is described. This approach involves a one‐pot hydroxysulfonylation reaction through a photocatalytic redox process. The use of Na 2 Eosin Y as photocatalyst and blue light allows the access to a broad range of α‐hydroxysulfonylamides bearing a quaternary center in moderate to good yields with complete regioselectivity via radical process.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202300535