The role of the HGF/c-MET pathway on perineural invasion of pancreatic carcinoma

Conclusions: HGF/c-MET signaling pathway could not only enhance pancreatic cancer cell invasiveness to promote the pancreatic cancer cells to infiltrate into nerve tissues, but also promote the expression of neurotrophic factor in pancreatic cancer cells to induce nerve growth and tropism, which tog...

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Published inPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 16; no. 1; p. S38
Main Authors Nan, Ligang, Ma, Qingyong
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier India Pvt Ltd 01.01.2016
Elsevier Limited
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Summary:Conclusions: HGF/c-MET signaling pathway could not only enhance pancreatic cancer cell invasiveness to promote the pancreatic cancer cells to infiltrate into nerve tissues, but also promote the expression of neurotrophic factor in pancreatic cancer cells to induce nerve growth and tropism, which together lead to the occurrence of PNI.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2015.12.117