Diverse Cobalt(II) and Iron(II/III) Coordination Complexes/Polymers Based on 4′-Pyridyl: 2,2′;6′,2″-Terpyridine: Synthesis, Structures, Catalytic and Anticancer Activities

The success of platinum-based chemotherapeutic drugs for clinical cancer treatments has inspired tremendous research efforts on developing new metallic anticancer agents with improved cytotoxic activity and reduced side effects. 2,2′;6′,2″-Terpyridine and its 4′-substituted derivatives have showed g...

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Published inChemistry an international journal Vol. 6; no. 5; pp. 1099 - 1110
Main Authors Cheng, Shu-Yuan, Zhang, Qinguo, Tang, Quan, Neary, Michelle C., Zheng, Shengping
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 24.09.2024
Subjects
2,2
6′,2″-terpyridine
Anticancer properties
Cancer therapies
Chemical synthesis
Cobalt
Cobalt compounds
cobalt(II)
Coordination compounds
coordination polymer
Coordination polymers
Crystallography
Cytotoxicity
Drugs
Epithelium
Hydrosilylation
Iron
iron(II/III)
Ligands
Metals
Polymers
Polymorphism
Side effects
Solvents
Structural analysis
United States > US
Japan
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Summary:The success of platinum-based chemotherapeutic drugs for clinical cancer treatments has inspired tremendous research efforts on developing new metallic anticancer agents with improved cytotoxic activity and reduced side effects. 2,2′;6′,2″-Terpyridine and its 4′-substituted derivatives have showed great potential as ligand compartments for designing new anticancer drug candidates involving base metals. In this work, we synthesized a series of cobalt and iron coordination compounds based on 4′-pyridyl-2,2′;6′,2″-terpyridine, including homoleptic complexes, a dinuclear bridged complex and 1- and 2-dimensional coordination polymers/networks. The polymorphism of two homoleptic CoII and FeII complexes has been described along with the structural characterization of a CoII coordination polymer and dinuclear FeIII complex by X-ray crystallography. These compounds were tested preliminarily as precatalysts for the regioselective hydrosilylation of styrene. Their cytotoxic activities against two human breast cancer cell lines (MCF-7 and MDA-MB 468) and a normal breast epithelial cell line (MCF-10A) were investigated in order to observe the best-performing drug candidates.
ISSN:2624-8549
2624-8549
DOI:10.3390/chemistry6050064