Pregabalin-Induced Bullous Pemphigoid: A Case Report of a Rare Drug-Triggered Autoimmune Skin Disorder

Bullous pemphigoid (BP) is a common autoimmune blistering disorder primarily affecting the elderly, characterized by intense pruritus and tense bullae on the skin. We report the case of a 75-year-old female with a history of breast cancer who developed BP on both feet following the initiation of pre...

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 9; p. e69649
Main Authors Tovar, Rachel, Jones, Daniel T, Srinivasmurthy, Ramaditya, Pandit, Meghana, Ho, Liawaty
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 18.09.2024
Cureus
Subjects
Antibiotics
Antigens
Biopsy
Case reports
Dermatology
Diuretics
Drugs
Immunology
Immunosuppressive agents
Inflammation
Inhalers
Internal Medicine
Pathogenesis
Patients
Quality of life
Skin
Steroids
Symptom management
Tumor necrosis factor-TNF
pregabalin
bullous pemphigoid
topical corticosteroids
autoimmune skin disorder
drug-induced bullous diseases
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Summary:Bullous pemphigoid (BP) is a common autoimmune blistering disorder primarily affecting the elderly, characterized by intense pruritus and tense bullae on the skin. We report the case of a 75-year-old female with a history of breast cancer who developed BP on both feet following the initiation of pregabalin for pain management. Histopathological examination confirmed BP, and symptoms improved with topical corticosteroid treatment and discontinuation of pregabalin. This case highlights the potential of pregabalin to induce BP and underscores the importance of recognizing medication-induced bullous diseases for prompt diagnosis and management.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.69649