Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock

• Published in: NEJM evidence Vol. 2; no. 6; p. EVIDoa2300034
• Main Authors: Pirracchio, Romain, Annane, Djillali, Waschka, Andre K, Lamontagne, François, Arabi, Yaseen M, Bollaert, Pierre-Edouard, Billot, Laurent, Du, Bin, Briegel, Josef, Cohen, Jeremy, Finfer, Simon, Gordon, Anthony, Hammond, Naomi, Hyvernat, Herve, Keh, Didier, Li, Yi, Liu, Ling, Meduri, Gianfranco Umberto, Mirea, Liliana, Myburgh, John A, Sprung, Charles L, Tilouche, Neijla, Tongyoo, Surat, Venkatesh, Balasubramanian, Zheng, Ruiqiang, Delaney, Anthony
• Format: Journal Article
• Language: English
• Published: United States 01.06.2023
• Subjects: Adult; Humans; Hydrocortisone; Shock, Septic - drug therapy

Low-Dose Hydrocortisone and Septic ShockCorticosteroids have been evaluated as a therapy for septic shock for more than 50 years. However, uncertainty persists about their effects on mortality. Pirracchio and colleagues undertake a patient-level meta-analysis to answer this important question.