Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock

Low-Dose Hydrocortisone and Septic ShockCorticosteroids have been evaluated as a therapy for septic shock for more than 50 years. However, uncertainty persists about their effects on mortality. Pirracchio and colleagues undertake a patient-level meta-analysis to answer this important question.

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Bibliographic Details
Published inNEJM evidence Vol. 2; no. 6; p. EVIDoa2300034
Main Authors Pirracchio, Romain, Annane, Djillali, Waschka, Andre K, Lamontagne, François, Arabi, Yaseen M, Bollaert, Pierre-Edouard, Billot, Laurent, Du, Bin, Briegel, Josef, Cohen, Jeremy, Finfer, Simon, Gordon, Anthony, Hammond, Naomi, Hyvernat, Herve, Keh, Didier, Li, Yi, Liu, Ling, Meduri, Gianfranco Umberto, Mirea, Liliana, Myburgh, John A, Sprung, Charles L, Tilouche, Neijla, Tongyoo, Surat, Venkatesh, Balasubramanian, Zheng, Ruiqiang, Delaney, Anthony
Format Journal Article
LanguageEnglish
Published United States 01.06.2023
Subjects
Adult
Humans
Hydrocortisone
Shock, Septic - drug therapy
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Summary:Low-Dose Hydrocortisone and Septic ShockCorticosteroids have been evaluated as a therapy for septic shock for more than 50 years. However, uncertainty persists about their effects on mortality. Pirracchio and colleagues undertake a patient-level meta-analysis to answer this important question.
ISSN:2766-5526
DOI:10.1056/EVIDoa2300034