Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock
Low-Dose Hydrocortisone and Septic ShockCorticosteroids have been evaluated as a therapy for septic shock for more than 50 years. However, uncertainty persists about their effects on mortality. Pirracchio and colleagues undertake a patient-level meta-analysis to answer this important question.
Saved in:
| Published in | NEJM evidence Vol. 2; no. 6; p. EVIDoa2300034 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.06.2023
|
| Subjects | |
| Online Access | Get more information |
Cover
Loading…
| Abstract | Low-Dose Hydrocortisone and Septic ShockCorticosteroids have been evaluated as a therapy for septic shock for more than 50 years. However, uncertainty persists about their effects on mortality. Pirracchio and colleagues undertake a patient-level meta-analysis to answer this important question. |
|---|---|
| AbstractList | Low-Dose Hydrocortisone and Septic ShockCorticosteroids have been evaluated as a therapy for septic shock for more than 50 years. However, uncertainty persists about their effects on mortality. Pirracchio and colleagues undertake a patient-level meta-analysis to answer this important question. |
| Author | Sprung, Charles L Briegel, Josef Zheng, Ruiqiang Gordon, Anthony Li, Yi Tilouche, Neijla Pirracchio, Romain Cohen, Jeremy Annane, Djillali Billot, Laurent Mirea, Liliana Bollaert, Pierre-Edouard Liu, Ling Tongyoo, Surat Arabi, Yaseen M Du, Bin Meduri, Gianfranco Umberto Delaney, Anthony Venkatesh, Balasubramanian Finfer, Simon Hyvernat, Herve Lamontagne, François Myburgh, John A Keh, Didier Waschka, Andre K Hammond, Naomi |
| Author_xml | – sequence: 1 givenname: Romain surname: Pirracchio fullname: Pirracchio, Romain organization: Department of Anesthesia and Perioperative Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco – sequence: 2 givenname: Djillali surname: Annane fullname: Annane, Djillali organization: FHU SEPSIS, U1173, University Paris Saclay, INSERM, Paris – sequence: 3 givenname: Andre K surname: Waschka fullname: Waschka, Andre K organization: Department of Mathematics, Mercer University, Macon, Georgia – sequence: 4 givenname: François surname: Lamontagne fullname: Lamontagne, François organization: Centre de recherche du CHU de Sherbrooke, Sherbrooke, QC, Canada – sequence: 5 givenname: Yaseen M surname: Arabi fullname: Arabi, Yaseen M organization: Intensive Care Department, Ministry of the National Guard-Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia – sequence: 6 givenname: Pierre-Edouard surname: Bollaert fullname: Bollaert, Pierre-Edouard organization: Intensive Care Unit, Hospital Central, Nancy, France – sequence: 7 givenname: Laurent surname: Billot fullname: Billot, Laurent organization: The George Institute for Global Health, University of New South Wales Sydney, Sydney – sequence: 8 givenname: Bin surname: Du fullname: Du, Bin organization: State Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Beijing – sequence: 9 givenname: Josef surname: Briegel fullname: Briegel, Josef organization: Department of Anesthesiology, University Hospital, LMU Munich, Munich, Germany – sequence: 10 givenname: Jeremy surname: Cohen fullname: Cohen, Jeremy organization: Intensive Care Unit, The Royal Brisbane and Women's Hospital, University of Queensland, Brisbane, QLD, Australia – sequence: 11 givenname: Simon surname: Finfer fullname: Finfer, Simon organization: School of Public Health, Imperial College London, London – sequence: 12 givenname: Anthony surname: Gordon fullname: Gordon, Anthony organization: Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London – sequence: 13 givenname: Naomi surname: Hammond fullname: Hammond, Naomi organization: Newtown, NSW, Malcolm Fisher Department of Intensive Care, Royal North Shore Hospital, St. Leonards, NSW, Australia – sequence: 14 givenname: Herve surname: Hyvernat fullname: Hyvernat, Herve organization: Intensive Care Unit, Hôpital ARCHET 1-CHU de Nice, Nice, France – sequence: 15 givenname: Didier surname: Keh fullname: Keh, Didier organization: Klinik für Anästhsiologie m.S. Canpus Virchow-Klinikum, Charite University Berlin, Berlin – sequence: 16 givenname: Yi surname: Li fullname: Li, Yi organization: Chinese Academy of Medical Science and Peking Union Medical College, Beijing – sequence: 17 givenname: Ling surname: Liu fullname: Liu, Ling organization: Department of Critical Medicine, Zhong-Da Hospital, and School of Clinical Medicine, Southeast University, Nanjing, China – sequence: 18 givenname: Gianfranco Umberto surname: Meduri fullname: Meduri, Gianfranco Umberto organization: Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis – sequence: 19 givenname: Liliana surname: Mirea fullname: Mirea, Liliana organization: Anaesthesia and Intensive Care Clinic, Clinical Emergency Hospital of Bucharest, Carol Davila University of Medicine, Bucharest, Romania – sequence: 20 givenname: John A surname: Myburgh fullname: Myburgh, John A organization: The George Institute for Global Health, University of New South Wales Sydney, Sydney – sequence: 21 givenname: Charles L surname: Sprung fullname: Sprung, Charles L organization: Department of Anesthesiology, Critical Care and Pain Medicine, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem – sequence: 22 givenname: Neijla surname: Tilouche fullname: Tilouche, Neijla organization: Intensive Care Unit, University Hospital Taher Sfar Mahdia, University of Monastir, Research Laboratory, Monastir, Tunisia – sequence: 23 givenname: Surat surname: Tongyoo fullname: Tongyoo, Surat organization: Division of Critical Care, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand – sequence: 24 givenname: Balasubramanian surname: Venkatesh fullname: Venkatesh, Balasubramanian organization: Wesley Hospital, George Institute for Global Health, University of New South Wales, Sydney – sequence: 25 givenname: Ruiqiang surname: Zheng fullname: Zheng, Ruiqiang organization: Department of Critical Care Medicine, Northern Jiangsu People's Hospital; Clinical Medical College, Yangzhou University, Yangzhou, China – sequence: 26 givenname: Anthony surname: Delaney fullname: Delaney, Anthony organization: Northern Clinical School, Sydney Medical School, University of Sydney, Sydney |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38320130$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j09LwzAchoMobs4dvUq-QDR_mvza49imG1QUp15H2iQs2jWlyRz99g7U0wvP4Xl4r9B5G1qL0A2jd4xKdb_8WC-C5oJSKrIzNOagFJGSqxGaxvh5wlwWShXsEo1ELjhlgo7R64tO3raJlPbbNvjJJk1mrW6G6CMODpfhSBYhWrwaTB_q0CcfT13sWzwzhyZFfPRphze2S77Gm12ov67RhdNNtNO_naD3h-XbfEXK58f1fFaSmgFkROUKtOY1VBm4jDrBqMsro3IHBfCCGyscV0XupHBUanBKZsbmruDgAIDxCbr99XaHam_Ntuv9XvfD9v8c_wGcIVDl |
| CitedBy_id | crossref_primary_10_1056_NEJMc2307400 crossref_primary_10_36290_aim_2023_071 crossref_primary_10_1016_j_biopha_2023_115961 crossref_primary_10_3390_microorganisms11092231 crossref_primary_10_1055_a_2128_5319 crossref_primary_10_1093_trstmh_trae017 crossref_primary_10_1056_EVIDe2300105 crossref_primary_10_1097_CCM_0000000000006207 crossref_primary_10_1016_S2213_2600_23_00470_8 crossref_primary_10_1055_s_0044_1787991 crossref_primary_10_1007_s00134_023_07179_5 crossref_primary_10_1007_s00134_024_07381_z crossref_primary_10_1097_ALN_0000000000004958 crossref_primary_10_1016_S2213_2600_23_00430_7 crossref_primary_10_1001_jama_2024_6096 crossref_primary_10_1016_j_resuscitation_2023_109922 crossref_primary_10_1164_rccm_202310_1785OC crossref_primary_10_1164_rccm_202401_0175ED crossref_primary_10_1097_CCM_0000000000006161 crossref_primary_10_1097_CCM_0000000000006172 crossref_primary_10_1097_CCE_0000000000001000 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1056/EVIDoa2300034 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| EISSN | 2766-5526 |
| ExternalDocumentID | 38320130 |
| Genre | Meta-Analysis Journal Article |
| GroupedDBID | 53G AABVL AAEXC ABBLC ABJNI ACPFK ADXNH AERZD AKUJG ALMA_UNASSIGNED_HOLDINGS CGR CUY CVF EBS ECM EIF NPM OVD SJN TEORI |
| ID | FETCH-LOGICAL-c1774-6867aa2c7b47f40f310f8bd68f797292de3f2698f53f05a7f654de8f927f77712 |
| IngestDate | Tue Oct 29 09:17:54 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c1774-6867aa2c7b47f40f310f8bd68f797292de3f2698f53f05a7f654de8f927f77712 |
| OpenAccessLink | https://evidence.nejm.org/doi/pdf/10.1056/EVIDoa2300034 |
| PMID | 38320130 |
| ParticipantIDs | pubmed_primary_38320130 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-Jun |
| PublicationDateYYYYMMDD | 2023-06-01 |
| PublicationDate_xml | – month: 06 year: 2023 text: 2023-Jun |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | NEJM evidence |
| PublicationTitleAlternate | NEJM Evid |
| PublicationYear | 2023 |
| SSID | ssj0002596691 |
| Score | 2.275118 |
| SecondaryResourceType | review_article |
| Snippet | Low-Dose Hydrocortisone and Septic ShockCorticosteroids have been evaluated as a therapy for septic shock for more than 50 years. However, uncertainty persists... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | EVIDoa2300034 |
| SubjectTerms | Adult Humans Hydrocortisone Shock, Septic - drug therapy |
| Title | Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38320130 |
| Volume | 2 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LTuswELUKSFdsEIh7eSMv2FWGxontdIloUUFthS4PsUOOY0N4NAgVIdjz34xjp20QiMcmquI2jXxOxjPOzBmEtnQUJKmOGAH7G5NIpprIUFJilAzDSLCUBrZ2uNfnndPo8Jyd12qvE1lLj8NkW718WFfyG1ThHOBqq2R_gOzoonACPgO-cASE4fgtjI-cKCrp2syfek8PJZkUGenmT6Rl89E7zymsU7ltvJw7lZBdK7vhK9uObWKLqh9f5V4g3_uq_fZhr65919GRCc0eHqRSV1nu8rLvZDailxVjdhukrWvbzOg2G2_XQxB9I0cZlOPN1a7tdjSUlz7NGFbO4tW9yLPKhgQNx4lT27owXFRwThhzlfCllaUTZJq0mO2zg1YuIRCySjkf2nRw0QCIT78HkNzfFQBDsE3ti9ivR99JbJdDU2hKxNZY9v2Wj13OIT7kvBl4fVa4mZ3KrcyiP-XP30UmhYdyMo_mfGiBdx1PFlBNDxbR_wpHcIUjODe45AiucgRnA-w4gi1HsOMILjjyF53ut0_2OsT30SAqAO-e8JgLKakSSSRM1DDg0Zs4SXlsRBNiK5rq0FDejA0LTYNJYTiLUh2bJhVGCBHQf2h6AH-9jDCnVAWp1DRI4EoanmpDIWDQMEVGM9VYQUtuCi7unVjKRTk5q5-OrKHZMY3W0YyBp1NvgKs3TDYLKN4AnJVS4A |
| link.rule.ids | 783 |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Patient-Level+Meta-Analysis+of+Low-Dose+Hydrocortisone+in+Adults+with+Septic+Shock&rft.jtitle=NEJM+evidence&rft.au=Pirracchio%2C+Romain&rft.au=Annane%2C+Djillali&rft.au=Waschka%2C+Andre+K&rft.au=Lamontagne%2C+Fran%C3%A7ois&rft.date=2023-06-01&rft.eissn=2766-5526&rft.volume=2&rft.issue=6&rft.spage=EVIDoa2300034&rft_id=info:doi/10.1056%2FEVIDoa2300034&rft_id=info%3Apmid%2F38320130&rft_id=info%3Apmid%2F38320130&rft.externalDocID=38320130 |