Sepsis Code: dodging mortality in a tertiary hospital

• Published in: Revista española de quimioterapia Vol. 35; no. 1; pp. 43 - 49
• Main Authors: Méndez, R, Figuerola, A, Chicot, M, Barrios, A, Pascual, N, Ramasco, F, Rodríguez, D, García, I, von Wernitz, A, Zurita, N, Semiglia, A, Jiménez, D, Navarro, S, Rubio, M J, Vinuesa, M, Del Campo, L, Bautista, A, Pizarro, A
• Format: Journal Article
• Language: English; Spanish
• Published: Spain 01.02.2022
• Subjects: Aftercare; Hospital Mortality; Humans; Patient Discharge; Retrospective Studies; Sepsis; Shock, Septic; Tertiary Care Centers; amines; mortality; creatinine; sepsis code; lactate
• ISSN: 0214-3429; 1988-9518
• DOI: 10.37201/req/105.2021

In the hospital of La Princesa, the "Sepsis Code" (CSP) began in 2015, as a multidisciplinary group that provides health personnel with clinical, analytical and organizational tools, with the aim of the detection and early treatment of patients with sepsis. The objective of this study is to evaluate the impact of CSP implantation on mortality and to determine the variables associated with an increase in it. A retrospective analytical study of patients with CSP alert activation from 2015 to 2018 was conducted. Clinical-epidemiological variables, analytical parameters, and severity factors such as admission to critical care units (UCC) and the need for amines were collected. Statistical significance was established at p < 0.05. We included 1,121 patients. The length of stay was 16 days and 32% required admission to UCC. Mortality showed a statistically significant linear downward trend from 24% in 2015 to 15% in 2018. The predictive mortality variables with statistically significant association were lactate > 2 mmol/L, creatinine > 1.6 mg/dL and the need for amines.>5.0%, mortality at the time of chart review 62.0%, and 6-months-post-discharge readmission 47.7%. The implementation of Sepsis Code decreases the mortality of patients with sepsis and septic shock. The presence of a lactate > 2 mmol/L, creatinine > 1.6 mg/dL and/or the need to administer amines in the first 24 hours, are associated with an increase in mortality in the patient with sepsis.