Pancreatic duct glands (PDG), a progenitor stem cell niche responsible for pancreatic epithelial renewal and repair in response to inflammatory injury

After migration, these tagged BrdU-positive cells lost the expression of PDG-specific markers such as Alcian blue, MUC6 and TFF2, but they acquired CK7 expression, a marker for the pancreatic duct epithelium, suggesting that these cells change their molecular characteristics during migration and bec...

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Published inPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 13; no. 2; p. e86
Main Authors Yamaguchi, J, Mino-Kenudson, M, Liss, A.S, Lillemoe, K.D, Fernández-del Castillo, C, Warshaw, A.L, Thayer., S.P
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier B.V 01.03.2013
Elsevier Limited
Subjects
Endocrinology & Metabolism
Gastroenterology and Hepatology
Migration
Pancreas
Rodents
Stem cells
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Summary:After migration, these tagged BrdU-positive cells lost the expression of PDG-specific markers such as Alcian blue, MUC6 and TFF2, but they acquired CK7 expression, a marker for the pancreatic duct epithelium, suggesting that these cells change their molecular characteristics during migration and become matured ductal cells.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2012.12.355