Review Article: Involvement of the Gut Microbiome and Probiotic Interventions in Pediatric Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a common pediatric cancer marked by uncontrolled proliferation of lymphoblasts, primarily affecting children aged two to five years. While treatment success rates have reached 90% in children, challenges such as therapy toxicity and relapse persist. The gut micr...

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Bibliographic Details
Published inCritical reviews in oncogenesis Vol. 30; no. 2; p. 13
Main Author Navasardyan, Inesa
Format Journal Article
LanguageEnglish
Published United States 2025
Subjects
Child
Child, Preschool
Gastrointestinal Microbiome - drug effects
Gastrointestinal Microbiome - immunology
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma - microbiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Probiotics - therapeutic use
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Summary:Acute lymphoblastic leukemia (ALL) is a common pediatric cancer marked by uncontrolled proliferation of lymphoblasts, primarily affecting children aged two to five years. While treatment success rates have reached 90% in children, challenges such as therapy toxicity and relapse persist. The gut microbiome, known to impact immune function, is often disrupted in ALL patients, potentially worsening with treatments like chemotherapy and antibiotics. Research suggests probiotics may help restore microbial balance and mitigate side effects, with certain strains showing promise in reducing gastrointestinal symptoms; however, their use requires caution in immunocompromised patients due to infection risks. Probiotics could improve treatment outcomes in ALL, but further research is needed to establish safe, standardized protocols for use in this sensitive population.
ISSN:0893-9675
DOI:10.1615/CritRevOncog.2025058176