Comparison of ethacridine lactate and prostaglandin E 2 in second trimester medical abortion
Background. A comparison of ethacridine lactate and prostaglandin E 2 (PGE 2 ) with or without oxytocin infusion in second trimester medical abortion cases. Methods. A prospective study was performed on 151 women requiring second trimester medical abortions between 1989 and 1995. Patients were rando...
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Published in | Acta obstetricia et gynecologica Scandinavica Vol. 76; no. 7; pp. 680 - 683 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
01.08.1997
|
Online Access | Get full text |
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Summary: | Background.
A comparison of ethacridine lactate and prostaglandin E
2
(PGE
2
) with or without oxytocin infusion in second trimester medical abortion cases.
Methods.
A prospective study was performed on 151 women requiring second trimester medical abortions between 1989 and 1995. Patients were randomly assigned to PGE
2
group (
n
= 30), ethacridine lactate group (
n
48), ethacridine lactate combined with oxytocin infusion group (
n
=49) and PGE
2
combined with oxytocin infusion group (
n
=24). Rates of successful abortion (i.e., complete evacuation of fetal and placental tissxies from the uterus) within 24 hours for each group were determined and compared by x
2
and the Student r‐test.
Results.
Statistically significant difference concerning successful abortion rates was observed between ethacridine lactate and PGE
2
groups, PGE
2
and PGE
2
+oxytocin infusion groups, and ethacridine lactate+oxytocin infusion and PGE
2
groups, while there was no significant difference between ethacridine lactate and ethacridine lactate+oxytocin infusion groups, ethacridine lactate and PGE
2
+oxytocin infusion groups, and PGE
2
+oxytocin infusion and ethacridine lactate+oxytocin infusion groups.
Conclusions.
Extra‐amniotic ethacridine lactate instillation alone and intracervical PGE
2
gel application are effective and safe methods for second trimester abortion. |
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ISSN: | 0001-6349 1600-0412 |
DOI: | 10.3109/00016349709024610 |