Functional impact of tumor-specific N-linked glycan changes in breast and ovarian cancers

• Published in: Advances in cancer research Vol. 126; pp. 281 - 303
• Main Authors: Guo, Huabei, Abbott, Karen L
• Format: Journal Article
• Language: English
• Published: United States 2015
• Subjects: Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Female; Glycomics - methods; Glycosylation; Humans; N-Acetylglucosaminyltransferases - metabolism; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Polysaccharides - chemistry; Polysaccharides - metabolism; Functional impact; N-linked; Breast; Tumor; Ovarian; Glycan; Cancer
• ISSN: 2162-5557
• DOI: 10.1016/bs.acr.2014.11.006

Changes in glycosylation have been implicated in various human diseases, including cancer. Research over the past few decades has produced significant findings that illustrate the importance of cancer-specific alterations in glycosylation in the regulation of tumor formation and metastasis. The identification of glycan-based biomarkers and strategies targeting specific glycan epitopes on the tumor cell surface has become one of the widely pursued research areas. In this chapter, we will summarize and provide perspective on available knowledge about the functional roles that glycan structures play in the development and progression of the gynecological cancers, breast and ovarian, with a specific focus on N-linked glycans. A better understanding of the functional roles for glycans in cancer will drive future innovations for diagnostics and therapeutics.