Comparative analysis of effectiveness of treatment with anti-TB drugs of the 1st and 2nd lines for children and adolescents with multidrug resistant tuberculosis

The paper shows results of study on comparative treatment effectiveness in children and adolescents with from multi drug resistant tuberculosis MDR TB (2000-2008) treated with anti-TB drugs of the 2nd line (80 patients) and 1st line (80 patients) in the Kazakhstan. It was stated in patients with MDR...

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Published inMedical and health science journal Vol. 11; no. 2; pp. 43 - 49
Main Authors Abildaev, Tleukhan, Bekembaeva, Gulbadan, Kastykpaeva, Larissa
Format Journal Article
LanguageEnglish
Published Prague Development Center 01.04.2012
Subjects
Antitubercular agents
Care and treatment
Children
Diseases
Health aspects
Tuberculosis
Kazakhstan
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Summary:The paper shows results of study on comparative treatment effectiveness in children and adolescents with from multi drug resistant tuberculosis MDR TB (2000-2008) treated with anti-TB drugs of the 2nd line (80 patients) and 1st line (80 patients) in the Kazakhstan. It was stated in patients with MDR TB that outcomes of treatment were successful in 91.2%, but relapse development of TB disease occurred in 12.7% of cases, and 5 (6.2%) patients died (P <0.05). Thus, patients with MDR TB need to be treated with anti-TB drugs of the 2nd line accordingly to their DST. Keywords: Multidrug resistance, children and adolescents, drugs of the 1st line, drugs of the 2nd line, TB disease relapse, drug sensitivity test (DST). UDC: [579.873.21:579.252.55].083.1:616-002.5-053.2-085-036.87
ISSN:1804-1884
1804-5014
DOI:10.15208/mhsj.2012.23