A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin

The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind. RGD sequences are commonly involved in cell adhesion. This sequence is crucial for transferrin binding, suggesting possible evolutionary links between molecu...

Full description

Saved in:
Bibliographic Details
Published inBiochemical journal Vol. 341; no. 1; pp. 11 - 14
Main Authors DUBLJEVIC, Valentina, SALI, Adnan, GODING, James W.
Format Journal Article
LanguageEnglish
Published 01.07.1999
Online AccessGet full text

Cover

More Information
Summary:The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind. RGD sequences are commonly involved in cell adhesion. This sequence is crucial for transferrin binding, suggesting possible evolutionary links between molecules mediating iron uptake and cell adhesion.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj3410011