Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma: A brief report of a rare neoplasm diagnosed with cytopathology on a splenic biopsy

Splenic biopsies for cytology remain challenging due to the inherent difficulty in obtaining adequate samples and the paucity of literature on rare entities arising in the spleen. Among these, are tumors arising from blood vessels, lymphomas and rarely, mesenchymal dendritic cell neoplasms. An impor...

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Bibliographic Details
Published inDiagnostic cytopathology
Main Authors Simoes, Nathalie J Rodrigues, Parra, Ourania, Schoolcraft, Daniel K, Karrs, Jeremiah X, Liu, Xiaoying
Format Journal Article
LanguageEnglish
Published United States 26.07.2024
Subjects
cytopathology
EBV‐positive IFDCS
splenic biopsy
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Summary:Splenic biopsies for cytology remain challenging due to the inherent difficulty in obtaining adequate samples and the paucity of literature on rare entities arising in the spleen. Among these, are tumors arising from blood vessels, lymphomas and rarely, mesenchymal dendritic cell neoplasms. An important but rarely considered entity primarily arising in the spleen is Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS). EBV+ IFDCS is an indolent neoplasm with useful cytomorphologic and distinct biologic characteristics that can be evaluated on fine-needle aspiration (FNA) cytology and small biopsies. In this report, we present a challenging case with the final diagnosis facilitated by cytomorphology and diagnostic markers in an ambiguous initial presentation.
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ISSN:8755-1039
1097-0339
1097-0339
DOI:10.1002/dc.25388