A double blind, placebo-controlled investigation of the effects of Mg/K substitution on metabolism in sympathoadrenal anticipation

• Published in: Trace elements and electrolytes Vol. 38; no. 1; pp. 28 - 32
• Main Authors: Porta, Sepp, Vormann, Jürgen, Bäck, Ines, Wörgötter, Jürgen, Kisters, Klaus, Stossier, Harald
• Format: Journal Article
• Language: English
• Published: Munich Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG 01.01.2021
• Subjects: Blood; Blood pressure; Double-blind studies; Electrolytes; Fatty acids; Glucose; Heart rate; Magnesium; Metabolism; Potassium; Workloads
• ISSN: 0946-2104
• DOI: 10.5414/TEX01649

A preparation of 300 mg magnesium and 360 mg potassium was given orally to 11 subjects 1 hour before a 2,400-m run. The same regimen was applied to 12 more subjects, but with placebo tablets. Immediately before the run, after the sympathoadrenal anticipation (SAA) phase, capillary blood was sampled from all participants, and pH, pCO2, ionized Mg (iMg), ionized K (iK), blood glucose, lactate, and base excess were determined by a Phox-M device). The test was performed in a double-blind manner. Group averages before the run (except iK and iMg) were not significantly different between the placebo and active-treatment group. However, in the placebo group, lactate (effort marker) correlated linearly with RRsys, which was not the case in supplemented persons. Likewise, in contrast to the placebo group, increase of heart rate along with RRsys in supplemented persons did not commence until ~ 130 mmHg. Also, contrary to the placebo group, supplemented persons show significant linear correlations between iK and iMg with the effort parameters non-lactate acidity (NLA) and lactate. We deduce that 1) mental effort per se has considerable metabolic impact, and 2) supplementation of Mg and K reduces that impact significantly.