Tuning of Surface Charge of Functionalized Poly(Carboxybetaine) Brushes Can Significantly Improve Label‐Free Biosensing in Complex Media (Adv. Mater. Interfaces 33/2022)

Poly(carboxybetaine) Functionalization Proper restoration of zwitterionic balance after functionalization of poly(carboxybetaine) brushes (pCB) is critical for pCB‐biorecognition coatings with excellent antifouling properties. In article number 2201210, Ivana Víšová, Milan Houska, Hana Vaisocherová‐...

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Published inAdvanced materials interfaces Vol. 9; no. 33
Main Authors Víšová, Ivana, Houska, Milan, Spasovová, Monika, Forinová, Michala, Pilipenco, Alina, Mezuláníková, Kateřina, Tomandlová, Markéta, Mrkvová, Kateřina, Vrabcová, Markéta, Dejneka, Alexandr, Dostálek, Jakub, Vaisocherová‐Lísalová, Hana
Format Journal Article
LanguageEnglish
Published 22.11.2022
Subjects
antifouling zwitterionic polymer brushes
biosensors
EDC/NHS chemistry
N‐hydroxysuccinimide (NHS) active ester deactivation
poly(carboxybetaine) functionalization
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Summary:Poly(carboxybetaine) Functionalization Proper restoration of zwitterionic balance after functionalization of poly(carboxybetaine) brushes (pCB) is critical for pCB‐biorecognition coatings with excellent antifouling properties. In article number 2201210, Ivana Víšová, Milan Houska, Hana Vaisocherová‐Lísalová, and colleagues present a method using tailor‐made mixtures of agents allowing tuning of the surface charge balance. This approach improves antifouling of functionalized pCBs by several orders of magnitude, which has a significant impact on label‐free biosensing in complex media.
ISSN:2196-7350
2196-7350
DOI:10.1002/admi.202270182