MMP-2 assessment as an indicator of wound healing: A feasibility study
Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing. Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface...
Saved in:
Published in | Advances in skin & wound care Vol. 19; no. 6; p. 324 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.07.2006
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Summary: | Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing.
Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface area, > or = 1 cm). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing.
Therapy-induced wound healing and immunohistochemical measurements of MMP-2 expression paralleled the clinical characteristics of wound healing.
MMP-2 expression offers a reliable indicator for clinical wound healing induced by DerMax treatment. |
---|---|
ISSN: | 1527-7941 |
DOI: | 10.1097/00129334-200607000-00011 |