MMP-2 assessment as an indicator of wound healing: A feasibility study

Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing. Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface...

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Bibliographic Details
Published inAdvances in skin & wound care Vol. 19; no. 6; p. 324
Main Authors Karim, Refaat B, Brito, Beatriz L R, Dutrieux, Richard P, Lassance, Fernanda P, Hage, J Joris
Format Journal Article
LanguageEnglish
Published United States 01.07.2006
Subjects
Adult
Aged
Bandages
Biomarkers - analysis
Biopsy
Drug Monitoring - methods
Feasibility Studies
Female
Humans
Immunohistochemistry - methods
Immunohistochemistry - standards
Leg Ulcer - pathology
Leg Ulcer - therapy
Male
Matrix Metalloproteinase 2 - analysis
Middle Aged
Phytotherapy
Plant Bark
Rubidium - administration & dosage
Rubidium - chemistry
Single-Blind Method
Wound Healing
Zinc - administration & dosage
Zinc - chemistry
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Summary:Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing. Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface area, > or = 1 cm). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing. Therapy-induced wound healing and immunohistochemical measurements of MMP-2 expression paralleled the clinical characteristics of wound healing. MMP-2 expression offers a reliable indicator for clinical wound healing induced by DerMax treatment.
ISSN:1527-7941
DOI:10.1097/00129334-200607000-00011